Octanoic acid
Octanoic acid is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target hydroxycarboxylic acid receptor 3 and cytochrome P450 4Z1.
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2Y
5Y
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
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Completion date
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Commercial
No data
Clinical
Clinical Trials
90 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Primary immunodeficiency diseases | D000081207 | — | — | — | 1 | 3 | 2 | — | 6 |
| Immunologic deficiency syndromes | D007153 | — | D84.9 | — | 1 | 1 | 2 | — | 4 |
| Immune system diseases | D007154 | — | D89.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myasthenia gravis | D009157 | EFO_0004991 | G70.0 | — | 1 | 1 | — | — | 2 |
| Muscle weakness | D018908 | — | — | — | 1 | 1 | — | — | 2 |
| Agammaglobulinemia | D000361 | — | D80.1 | — | 1 | 1 | — | — | 2 |
| Chronic inflammatory demyelinating polyradiculoneuropathy | D020277 | EFO_1000868 | G61.81 | — | — | 1 | — | — | 1 |
| Wiskott-aldrich syndrome | D014923 | EFO_0003903 | D82.0 | — | — | 1 | — | — | 1 |
| Severe combined immunodeficiency | D016511 | — | D81.0 | — | — | 1 | — | — | 1 |
| Common variable immunodeficiency | D017074 | EFO_0000367 | D83 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | — | 1 |
| Diabetes complications | D048909 | — | — | — | 1 | — | — | — | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | — | — | — | 1 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 1 | — | — | — | 1 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 1 | — | — | — | 1 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | 1 | — | — | — | 1 |
| Thrombocytopenic purpura idiopathic | D016553 | EFO_0007160 | D69.3 | — | 1 | — | — | — | 1 |
| Thrombocytopenic purpura | D011696 | — | — | — | 1 | — | — | — | 1 |
| Lung transplantation | D016040 | — | — | — | 1 | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Octanoic acid |
| INN | octanoic acid |
| Description | Octanoic acid is a straight-chain saturated fatty acid that is heptane in which one of the hydrogens of a terminal methyl group has been replaced by a carboxy group. Octanoic acid is also known as caprylic acid. It has a role as an antibacterial agent, a human metabolite and an Escherichia coli metabolite. It is a straight-chain saturated fatty acid and a medium-chain fatty acid. It is a conjugate acid of an octanoate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCCCCC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 124-07-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL324846 |
| ChEBI ID | 28837 |
| PubChem CID | 379 |
| DrugBank | DB04519 |
| UNII ID | OBL58JN025 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
HCAR3
HCAR3
CYP4Z1
CYP4Z1
Organism
Homo sapiens
Gene name
HCAR3
Gene synonyms
GPR109B, HCA3, HM74B, NIACR2
NCBI Gene ID
Protein name
hydroxycarboxylic acid receptor 3
Protein synonyms
G-protein coupled receptor 109B, G-protein coupled receptor HM74, G-protein coupled receptor HM74B, GTP-binding protein, hydroxy-carboxylic acid receptor 3, Niacin receptor 2, Nicotinic acid receptor 2, putative chemokine receptor
Uniprot ID
Mouse ortholog
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Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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22 adverse events reported
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